Regeneration

A complete spinal cord injury results, tragically, in total paralysis of all limbs and muscles below the injury site. But now, scientists at EPFL have demonstrated in mice a new gene therapy that can regenerate nerves and restore the ability to walk.

Scientists at Daegu Gyeongbuk Institute of Science & Technology (DGIST) in South Korea have developed a novel bioelectric therapy that restored muscle cells in aging mice, and they’re confident of its promise to have a similar effect in human models.

A new technique may one day help restore sight to patients with inherited vision impairment. The regenerative therapy works by expressing genes that convert dormant cells into new light-sensing cells in the retina to replace those lost to disease.

An international team of scientists has found a way to regenerate kidneys damaged by disease, restoring function and preventing kidney failure. The discovery could help improve treatments for complications stemming from diabetes and other diseases.

A torn meniscus, the cartilage in the knee, is a common sports injury, and unfortunately it doesn’t heal well. But researchers in Japan have now identified a hormone that helps repair the cartilage after a surgical treatment.

Researchers have demonstrated a new technique for helping heart cells regenerate after a heart attack, using mRNA to return the cells to a stem-cell-like state. Tests in mice showed drastic improvements to heart function a month after a heart attack.

The liver can regenerate itself after taking damage, but whether that ability fades with age is unknown. A new study has found that age doesn’t slow down the liver’s regeneration, and whether you’re 20 or 80, your liver is on average just three years old.

Tendon injuries are painful and don’t always heal properly. Researchers at the Terasaki Institute have now shown that silk scaffolds loaded with stem cells can help tendons regenerate more effectively.

Animals like axolotls can regrow fully functional replacements for lost limbs. In a breakthrough new study, scientists have demonstrated how one dose of a drug cocktail can regrow lost limbs in frogs that don’t normally have regenerative abilities.

After an injury, nerves struggle to regrow completely, leaving patients with reduced mobility and sensation. In tests on rats, researchers have now demonstrated a way to improve nerve repair using proteins from the support network around cells.

Lizards can regrow their tails, but the new tail isn't quite perfect. Scientists have now used stem cell therapy to let lizards grow better tails – bones, nerves and all – in an advance that could have implications for better wound healing in humans.

Researchers at Salk Institute have uncovered a mechanism by which stem cells can help regenerate muscles. The discovery could provide a new drug target for repairing muscles after injury or rebuilding muscle mass lost during the normal aging process.