Spinal

A complete spinal cord injury results, tragically, in total paralysis of all limbs and muscles below the injury site. But now, scientists at EPFL have demonstrated in mice a new gene therapy that can regenerate nerves and restore the ability to walk.

Loss of arm and hand mobility is a common and devastating disability among stroke survivors, but a promising new study shows how cervical spinal cord stimulation could improve limb function and restore quality of life.

Electrical spinal stimulation can help paralyzed people walk again. In a promising new clinical trial, scientists have identified the specific neurons being stimulated, and found that patients can still walk even after the implant was turned off.

In a world-first clinical trial, three babies have been born after receiving stem cell treatment for spina bifida. A stem cell patch is applied to the fetus’ spine while still developing in the womb, and early results are promising one year on.

A drug under investigation as a cancer treatment has shown exciting promise in a rather different branch of medical research, with scientists demonstrating how it can promote nerve repair following spinal injury.

Human trials have shown that hydrogel injections are a promising, effective treatment for chronic lower back pain caused by degenerative disc disease (DDD). The treatment is far less invasive than other surgeries, and has been given FDA approval.

In what is being described as a world-first, scientists in Israel have reportedly grown spinal cord implants utilizing tissue extracted from human volunteers. Those implants were then used to restore walking abilities to previously paralyzed mice.

As people get older, the intervertebral discs in their spine tend to deteriorate, some of which end up being surgically replaced with implants. A new patient-specific spinal model, however, could help determine how successful such surgery will be.

A new type of artificial scaffold encourages regenerating neurons to grow towards one another and bridge busted connections more efficiently, offering new hope for healing damaged spinal cords and restoring communication links between the brain and body.

Spinal cord injuries are among the most debilitating. In a new breakthrough study, Northwestern University researchers have developed a gel containing “dancing molecules” that allowed paralyzed mice to walk again four weeks after a single injection.

Scientists have shown how so-called senolytic drugs that remove destructive senescent cells can prevent age-related deterioration of spinal discs, raising the prospect of a new opioid-free treatment for back pain in humans.

By targeting the same mechanisms through which epidural anesthesia controls pain during child birth, engineers at the University of Cambridge have demonstrated a new medical implant that could offer relief from other types of severe pain.